What is A Postsynaptic Cell In Neuroscience?

What is a Postsynaptic Cell?

A postsynaptic cell is a neuron that receives signals from another neuron via a specialized structure called a synapse. In this context, the neuron sending the signal is known as the presynaptic cell. The postsynaptic cell receives and interprets chemical signals, in the form of neurotransmitters, from the presynaptic cell, which can either excite or inhibit the postsynaptic cell, thereby affecting its activity.

Key Features

  • Dendrites and Soma

    The dendrites and soma (cell body) of the neuron often serve as the main postsynaptic sites. These areas contain receptors that are activated by neurotransmitters released from the presynaptic neuron.

  • Postsynaptic Density

    The postsynaptic density is a region of the postsynaptic membrane that contains a high concentration of neurotransmitter receptors and other proteins involved in signal transmission and synaptic plasticity. This region plays a key role in receiving and processing signals from the presynaptic neuron.

  • Neurotransmitter Receptors

    Receptors located on the postsynaptic membrane bind to neurotransmitters released by the presynaptic cell. The binding of neurotransmitters can either excite the neuron, making it more likely to fire an action potential, or inhibit the neuron, making it less likely to fire.


  • Signal Reception

    The primary function of the postsynaptic cell is to receive signals from the presynaptic cell. This is accomplished through the binding of neurotransmitters to receptors on the postsynaptic membrane.

  • Signal Integration

    The postsynaptic cell integrates signals from multiple presynaptic neurons to determine whether or not to fire an action potential. This integration process is crucial for the complex information processing that underlies brain function.

  • Synaptic Plasticity

    Changes in the strength of the synapse, known as synaptic plasticity, occur in the postsynaptic cell. This process, which can be influenced by the frequency and intensity of presynaptic signals, is thought to underlie learning and memory.

Postsynaptic Cell and Neurological Disorders

Dysfunction in the postsynaptic cell can contribute to a variety of neurological and psychiatric disorders. For instance, changes in the number or function of postsynaptic receptors can lead to conditions such as depression, schizophrenia, and Alzheimer’s disease. Understanding the functions and mechanisms of the postsynaptic cell is therefore crucial for the development of effective treatments for these disorders.

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